![]() Silver Sulfadiazine Cream 1% is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation.īecause sulfonamide therapy is known to increase the possibility of kernicterus, Silver Sulfadiazine Cream 1% should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life. ![]() Silver Sulfadiazine Cream 1% is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Indications and Usage for Silver Sulfadiazine Cream Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated. Results of In Vitro Testing with Silver Sulfadiazine Cream 1% Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Results from in vitro testing are listed below. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Silver sulfadiazine has broad antimicrobial activity. Silver Sulfadiazine Cream - Clinical Pharmacology Silver Sulfadiazine Cream 1% spreads easily and can be washed off readily with water. The cream vehicle consists of white petrolatum, stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene glycol, and water, with methylparaben 0.3% as a preservative. The unwanted effects may improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.Each gram of Silver Sulfadiazine Cream 1% contains 10 mg of micronized silver sulfadiazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The table below contains some of the ones associated with silver sulfadiazine. ![]() Doing this will further reduce the risk of infection.Īlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. It is likely you will be asked to apply the cream while wearing a sterile glove or by using a sterile applicator.Your doctor will tell you how often is right for you, and this information will be on the label of the pack to remind you. Depending upon the reason you are using the cream, you may be directed to use it each day or several times a week.It will give you more information about the cream and will provide you with a full list of the side-effects that you may experience from using it. Before you start using the preparation, read the manufacturer's printed information leaflet from inside the pack. ![]()
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